The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 24, 2022

Filed:

Jun. 18, 2019
Applicants:

Children's Hospital Los Angeles, Los Angeles, CA (US);

Nanovalent Pharmaceuticals, Inc., Bozeman, MT (US);

Inventors:

Jon O. Nagy, Bozeman, MT (US);

Tim Triche, Los Angeles, CA (US);

Hyung-Gyoo Kang, Buena Park, CA (US);

Assignees:

Children's Hospital Los Angeles, Los Angeles, CA (US);

Nanovalent Pharmaceuticals, Inc., Bozeman, MT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 45/06 (2006.01); A61K 9/51 (2006.01); A61K 31/136 (2006.01); A61K 31/337 (2006.01); A61K 31/407 (2006.01); A61K 31/4745 (2006.01); A61K 31/475 (2006.01); A61K 31/573 (2006.01); A61K 31/704 (2006.01); A61K 31/7068 (2006.01); A61K 31/713 (2006.01); A61K 33/243 (2019.01);
U.S. Cl.
CPC ...
A61K 9/1273 (2013.01); A61K 9/1271 (2013.01); A61K 9/51 (2013.01); A61K 31/136 (2013.01); A61K 31/337 (2013.01); A61K 31/407 (2013.01); A61K 31/475 (2013.01); A61K 31/4745 (2013.01); A61K 31/573 (2013.01); A61K 31/704 (2013.01); A61K 31/7068 (2013.01); A61K 31/713 (2013.01); A61K 45/06 (2013.01); A61K 33/243 (2019.01); Y10S 977/773 (2013.01); Y10S 977/906 (2013.01); Y10S 977/907 (2013.01);
Abstract

The invention relates to a novel drug delivery vehicle. Various embodiments of the invention provide a hybrid polymerized liposomal nanoparticle comprising both polymerizable lipids and non-polymerizable lipids. Therapeutic agents can be loaded into the polymerized liposomal nanoparticle and targeting agents can be conjugated to the surface of the polymerized liposomal nanoparticle. Also described in the invention are methods, compositions and kits that utilize the hybrid polymerized liposomal nanoparticle to treat disease conditions such as various cancers.


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