The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 24, 2022

Filed:

Nov. 18, 2019
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

William G. Austen, Jr., Weston, MA (US);

Michael McCormack, Medford, MA (US);

Robert W. Redmond, Lancaster, MA (US);

Irene E. Kochevar, Boston, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61F 2/06 (2013.01); A61K 41/00 (2020.01); A61L 27/36 (2006.01); A61N 5/06 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01); A61L 31/00 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01);
U.S. Cl.
CPC ...
A61F 2/06 (2013.01); A61K 41/0057 (2013.01); A61L 27/3604 (2013.01); A61L 27/3633 (2013.01); A61L 27/50 (2013.01); A61L 27/505 (2013.01); A61L 27/54 (2013.01); A61L 31/005 (2013.01); A61L 31/14 (2013.01); A61L 31/16 (2013.01); A61N 5/0601 (2013.01); A61N 5/062 (2013.01); A61L 2300/418 (2013.01); A61L 2300/424 (2013.01); A61L 2300/442 (2013.01); A61L 2400/18 (2013.01); A61L 2430/04 (2013.01); A61L 2430/22 (2013.01); A61L 2430/34 (2013.01); A61N 5/0603 (2013.01); A61N 5/0624 (2013.01);
Abstract

One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent ('TSSA') under conditions sufficient to promote cross-linking of proteins within the vein.


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