The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2022
Filed:
Aug. 05, 2020
Applicant:
Biomadison, Inc., Del Mar, CA (US);
Inventors:
Ward C. Tucker, Monona, WI (US);
Timothy M. Piazza, McFarland, WI (US);
Assignee:
BioMadison, Inc., Del Mar, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/569 (2006.01); G01N 21/64 (2006.01); C12Q 1/37 (2006.01); C12Q 1/6897 (2018.01); A47C 15/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/56911 (2013.01); A47C 15/006 (2013.01); C12Q 1/37 (2013.01); C12Q 1/6897 (2013.01); G01N 21/6408 (2013.01); G01N 21/6428 (2013.01); G01N 2333/33 (2013.01);
Abstract
Methods for increasing specific uptake of aneurotoxin are provided. Specific neurotoxin uptake by cells capable of being intoxicated byneurotoxin is enhanced by increasing temperature from about 37° C. to up to about 41° C., as indicated by a decrease in the ECfound for cells so treated. The effect requires the presence of both heavy and light chains of theneurotoxin, and is serotype selective.