The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2022
Filed:
Mar. 20, 2017
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventor:
Henry Daniell, Media, PA (US);
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/82 (2006.01); C07K 14/65 (2006.01); C07K 14/755 (2006.01); A61K 39/12 (2006.01); A61P 31/14 (2006.01); A61P 1/02 (2006.01); A61K 9/68 (2006.01); C07K 14/47 (2006.01); C12N 7/00 (2006.01); C12N 9/26 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8258 (2013.01); A61K 9/0058 (2013.01); A61K 39/12 (2013.01); A61P 1/02 (2018.01); A61P 31/14 (2018.01); C07K 14/4723 (2013.01); C07K 14/65 (2013.01); C07K 14/755 (2013.01); C12N 7/00 (2013.01); C12N 9/2408 (2013.01); C12N 15/8214 (2013.01); C12N 15/8216 (2013.01); C12N 15/8257 (2013.01); C12Y 302/01084 (2013.01); A61K 2039/542 (2013.01); A61K 2039/545 (2013.01); A61K 2039/575 (2013.01); A61K 2039/6037 (2013.01); C07K 2319/00 (2013.01); C12N 2770/32634 (2013.01);
Abstract
Methods for improving transgene in chloroplasts are disclosed along with improved transgenes so produced and methods of use thereof for the treatment of disease. Specifically, the methods comprising analyzing the native sequence of a nucleic acid encoding a protein of interest and replacing codons in said sequence with those preferentially used in psbA genes in chloroplasts in higher plants.