The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 17, 2022

Filed:

Feb. 21, 2017
Applicant:

Teknologian Tutkimuskeskus Vtt Oy, Espoo, FI;

Inventors:

Dominik Mojzita, Vtt, FI;

Anssi Rantasalo, Vtt, FI;

Jussi Jäntti, Vtt, FI;

Christopher Landowski, Vtt, FI;

Joosu Kuivanen, Vtt, FI;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/79 (2006.01); C07H 21/04 (2006.01); C12P 21/06 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C12N 15/79 (2013.01); C12N 15/625 (2013.01); C07H 21/04 (2013.01); C07K 2319/09 (2013.01); C12N 2310/122 (2013.01); C12N 2310/531 (2013.01); C12N 2510/00 (2013.01);
Abstract

The present invention provides an expression system for a eukaryotic host, which comprises 1) an expression cassette comprising a core promoter, the core promoter controlling the expression of a DNA sequence encoding a synthetic transcription factor (sTF), and 2) one or more expression cassettes each comprising a DNA sequence encoding a desired product operably linked to a synthetic promoter, the synthetic promoter comprising a core promoter, and sTF-specific binding sites upstream of the core promoter. The present invention also provides a method for identifying universal core promoters for eukaryotic hosts, expression systems using universal core promoters, hosts comprising the systems, and methods for producing protein products in eukaryotic hosts.


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