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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11332727 B1

PDFFull Text
Date of Patent:
May. 17, 2022

Filed:

Mar. 13, 2018

Method for reducing an immune response by administering an immune evading adeno-associated aav8 or aavdj viral vector

Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Prashant Mali, La Jolla, CA (US);

Ana Moreno Collado, La Jolla, CA (US);

Nathan Palmer, La Jolla, CA (US);

Assignee:

The Regents of the University of California, Oakland, CA (US);

Attorney:

Gavrilovich, Dodd & Lindsey LLP

Primary Examiner:

Robert S Landsman

Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/86 (2006.01); A61K 49/00 (2006.01); G01N 33/50 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A61K 48/005 (2013.01); A61K 49/0008 (2013.01); C12N 15/111 (2013.01); C12N 15/86 (2013.01); G01N 33/50 (2013.01); C12N 2310/20 (2017.05); C12N 2750/14143 (2013.01);
Abstract

Described herein are methods of avoiding an immune response in a subject being administered a regimen requiring Cas9 in order to optimize and broaden the application of CRIPSR based therapeutics comprising administering immune orthogonal Cas9. Also described herein are methods to modify a Cas9 protein by swapping highly immunogenic peptides or amino acids with less immunogenic counterparts. These methods are particularly useful to enable the application of Cas9 arsenal for repeat treatments. Further provided are Cas9 proteins modified to reduce immunogenicity.

Find Patent Forward Citations

Mali, Prashant. (2022). Method for reducing an immune response by administering an immune evading adeno-associated aav8 or aavdj viral vector (U.S. Patent No. 11332727). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11332727

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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