The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 17, 2022

Filed:

Apr. 30, 2019
Applicants:

Eberhard Karls Universität Tübingen Medizinische Fakultät, Tübingen, DE;

Helmholtz-zentrum Für Infektionsforschung Gmbh Für Das Helmholtz-institut Für Pharmazeutische Forschung Saarland (Hips), Saarbrücken, DE;

Inventors:

Michael Kormann, Weil im Schönbuch, DE;

Lauren Mays Weddle, Newport, KY (US);

Claus-Michael Lehr, Saarbrücken-Dudweiler, DE;

Brigitta Loretz, Saarbrücken, DE;

Emad Malaeksefat, Heidelberg, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/115 (2010.01); C07K 14/47 (2006.01); C07K 14/785 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); C12N 15/111 (2013.01); C12N 15/115 (2013.01); C07K 14/4712 (2013.01); C07K 14/785 (2013.01); C12N 2310/16 (2013.01); C12N 2310/335 (2013.01); C12N 2310/3341 (2013.01); C12N 2310/3519 (2013.01);
Abstract

The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.


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