The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 17, 2022

Filed:

May. 25, 2018
Applicant:

Venatorx Pharmaceuticals, Inc., Malvern, PA (US);

Inventors:

Christopher J. Burns, Malvern, PA (US);

Denis Daigle, Street, MD (US);

Guo-Hua Chu, Exton, PA (US);

Jodie Hamrick, New Holland, PA (US);

Matthew Lucas, Cambridge, MA (US);

Steven A. Boyd, Chester Springs, PA (US);

Allison L. Zulli, Chesterbrook, PA (US);

Eugen F. Mesaros, Wallingford, PA (US);

Stephen M. Condon, Glenmoore, PA (US);

Robert E. Lee Trout, Collegeville, PA (US);

Cullen L. Myers, Exton, PA (US);

Assignee:

VENATORX PHARMACEUTICALS, INC., Malvern, PA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07F 5/02 (2006.01); A61P 31/04 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01);
U.S. Cl.
CPC ...
C07F 5/027 (2013.01); A61K 9/205 (2013.01); A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2059 (2013.01); A61K 9/4858 (2013.01); A61P 31/04 (2018.01);
Abstract

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.


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