The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2022
Filed:
Mar. 24, 2020
Applicant:
H. Lundbeck A/s, Valby, DK;
Inventors:
Carla De Faveri, Farra di Soligo TV, IT;
Florian Anton Martin Huber, Dolo VE, IT;
Assignee:
H. Lundbeck A/S, Valby, DK;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 498/04 (2006.01); C07D 491/113 (2006.01); C07D 211/78 (2006.01); C07C 269/04 (2006.01); C07C 227/22 (2006.01); C07C 227/18 (2006.01); C07C 249/02 (2006.01); C07C 271/22 (2006.01); C07C 229/08 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); C07C 227/18 (2013.01); C07C 227/22 (2013.01); C07C 229/08 (2013.01); C07C 249/02 (2013.01); C07C 269/04 (2013.01); C07C 271/22 (2013.01); C07D 211/78 (2013.01); C07D 491/113 (2013.01);
Abstract
The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to obtain the intermediate dimethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate or the intermediate diethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate.