The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 17, 2022

Filed:

Dec. 03, 2015
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Jeffrey T. Koberstein, Cataumet, MA (US);

Sanjoy Samanta, Selmabad, IN;

Chathuranga De Silva, New York, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/60 (2017.01); C08F 220/18 (2006.01); A61K 47/59 (2017.01); A61K 47/69 (2017.01); A61P 35/02 (2006.01); A61P 35/00 (2006.01); A01N 25/04 (2006.01); A01N 25/10 (2006.01); A61K 9/06 (2006.01); A61K 9/107 (2006.01); A61K 31/7068 (2006.01); C08G 65/333 (2006.01); C08G 65/48 (2006.01); C08G 81/00 (2006.01); C08J 3/075 (2006.01); C08J 3/24 (2006.01); C08L 33/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/60 (2017.08); A01N 25/04 (2013.01); A01N 25/10 (2013.01); A61K 9/06 (2013.01); A61K 9/1075 (2013.01); A61K 31/7068 (2013.01); A61K 47/59 (2017.08); A61K 47/6907 (2017.08); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C08F 220/18 (2013.01); C08G 65/33396 (2013.01); C08G 65/48 (2013.01); C08G 81/00 (2013.01); C08J 3/075 (2013.01); C08J 3/24 (2013.01); C08G 2230/00 (2013.01); C08G 2650/04 (2013.01); C08G 2650/30 (2013.01); C08G 2650/44 (2013.01); C08J 2371/08 (2013.01); C08L 33/06 (2013.01);
Abstract

The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.


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