The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 17, 2022

Filed:

Jan. 25, 2017
Applicants:

Massachusetts Eye and Ear Infirmary, Boston, MA (US);

University of Southern California, Los Angeles, CA (US);

Inventors:

Charles E. McKenna, Pacific Palisades, CA (US);

Boris A. Kashemirov, Los Angeles, CA (US);

Shuting Sun, Los Angeles, CA (US);

Kim Nguyen, Los Angeles, CA (US);

David Jung, Winchester, MA (US);

Michael J. McKenna, Southborough, MA (US);

William Sewell, Sherborn, MA (US);

Judith Kempfle, Brookline, MA (US);

Woo Seok Kang, Chestnut Hill, MA (US);

Albert Edge, Brookline, MA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/54 (2017.01); A61P 27/16 (2006.01); A61K 9/00 (2006.01); A61K 31/353 (2006.01); A61K 31/496 (2006.01); A61K 31/675 (2006.01); A61K 31/7088 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
A61K 47/548 (2017.08); A61K 9/0019 (2013.01); A61K 9/0046 (2013.01); A61K 31/353 (2013.01); A61K 31/496 (2013.01); A61K 31/675 (2013.01); A61K 31/7088 (2013.01); A61P 27/16 (2018.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 2310/20 (2017.05); C12N 2310/351 (2013.01); C12N 2800/80 (2013.01);
Abstract

This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.


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