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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11331345 B1

PDFFull Text
Date of Patent:
May. 17, 2022

Filed:

Apr. 21, 2019

Pd-1 car nk-92 cell and preparation method and use thereof

Applicant:

Asclepius (Suzhou) Technology Company Group Co., Ltd., Suzhou, CN;

Inventors:

Huashun Li, Suzhou, CN;

Baolei Wang, Suzhou, CN;

Kunkun Han, Suzhou, CN;

Baoyong Ren, Suzhou, CN;

Assignee:

ASCLEPIUS (SUZHOU) TECHNOLOGY COMPANY GROUP CO., LTD., Suzhou, CN;

Attorneys:

Flener IP & Business Law

Zareefa B. Flener

Primary Examiner:

Scott Long

Int. Cl.
CPC ...
A61K 35/17 (2015.01); C07K 14/47 (2006.01); A61P 35/00 (2006.01); C12N 15/86 (2006.01); A61K 48/00 (2006.01); C12N 15/62 (2006.01); C12N 15/867 (2006.01); C12N 5/10 (2006.01); C07K 19/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 48/00 (2013.01); A61P 35/00 (2018.01); C07K 14/4702 (2013.01); C07K 19/00 (2013.01); C12N 5/10 (2013.01); C12N 15/62 (2013.01); C12N 15/86 (2013.01); C12N 15/867 (2013.01);
Abstract

Provided are a PD-1 CAR NK-92 cell and a preparation method and use thereof. The PD-1 CAR NK-92 cell expresses PD-1-CD8™-4-1BB-CD3ζ fusion protein in NK-92 cells. The PD-1 CAR NK-92 is obtained by infecting an NK92 cell line with a PD-1 CAR molecule and obtaining monoclonal cells by means of flow screening, and culturing and expanding CAR NK92 monoclonal cell strains with stable traits and a high killing activity. The cells can be produced on a large scale, can be used in different patients without GVHR rejection, and have a specific killing activity and significant therapeutic effect on tumors.

Find Patent Forward Citations

Li, Huashun. (2022). Pd-1 car nk-92 cell and preparation method and use thereof (U.S. Patent No. 11331345). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11331345

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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