The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 17, 2022

Filed:

Mar. 19, 2020
Applicants:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

University of Maryland, Baltimore, Baltimore, MD (US);

Inventors:

Da-Wei Gong, Baltimore, MD (US);

James A. Perry, Baltimore, MD (US);

Alan Shuldiner, Tarrytown, NY (US);

Nehal Gosalia, Tarrytown, NY (US);

Cristopher Van Hout, Tarrytown, NY (US);

Assignees:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

University of Maryland, Baltimore, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 31/7105 (2006.01); C12N 9/22 (2006.01); C12Q 1/6827 (2018.01); C12Q 1/6853 (2018.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); C12N 9/22 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6853 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/20 (2017.05); C12N 2310/531 (2013.01);
Abstract

The present disclosure provides methods of treating subjects having increased lipid levels and/or increased triglyceride levels, methods of identifying subjects having an increased risk of developing an increased lipid level and/or increased triglyceride level, methods of detecting human Sterol Regulatory Element Binding Protein Cleavage-Activating Protein (SCAP) variant nucleic acid molecules and variant polypeptides, and SCAP variant nucleic acid molecules and variant polypeptides.


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