The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2022
Filed:
Jan. 17, 2018
Applicant:
Temasek Life Sciences Laboratory Limited, Singapore, SG;
Inventors:
Chang Zhi Adrian Ng, Singapore, SG;
Shen-Yi Ian Cheong, Singapore, SG;
Assignee:
Temasek Life Sciences Laboratory Limited, Singapore, SG;
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61P 35/00 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 47/02 (2006.01); A61K 47/12 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1271 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61P 35/00 (2018.01);
Abstract
Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.