The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2022
Filed:
Sep. 10, 2018
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Andrew Cho, New York, NY (US);
Roozbeh Eskandari, New York, NY (US);
Valentina Di Gialleonardo, New York, NY (US);
Kayvan R. Keshari, New York, NY (US);
MEMORIAL SLOAN KETTERING CANCER CENTER, New York, NY (US);
Abstract
The present technology providesC- andN-labeled probes for imaging one or more mammalian cells using magnetic resonance. Thus,C- andN-labeled arginine (compound of formula I), xanthine (compounds of formula II and formula III), urea (compounds of formula IV), and glutamine (compounds of formula V), stereoisomers, tautomers, and pharmaceutically acceptable salts thereof are provided. Further methods of making the labelled probes and methods of using the probes to detect arginase, xanthine oxidase, and glutaminase metabolites and activity are provided.