The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 10, 2022

Filed:

Sep. 21, 2018
Applicants:

Chang Gung University, Taoyuan, TW;

Chang Gung Memorial Hospital, Linkou, Taoyuan, TW;

Inventors:

Pao-Hsien Chu, Taoyuan, TW;

Yu-Sun Chang, New Taipei, TW;

Chia-Chun Chen, Taoyuan, TW;

Pei-Chun Fan, Taoyuan, TW;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); G16B 20/00 (2019.01); G16B 40/00 (2019.01); C12Q 1/6883 (2018.01); G16B 25/10 (2019.01); G16B 5/20 (2019.01);
U.S. Cl.
CPC ...
G16B 20/00 (2019.02); G16B 40/00 (2019.02); C12Q 1/6883 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01); G16B 5/20 (2019.02); G16B 25/10 (2019.02);
Abstract

A method for determining a human subject's risk of developing acute kidney injury (AKI) from acute myocardial infarction (AMI) includes: obtaining a blood sample; determining at least two miRNA expression levels therein, which are selected from miR-23a-3p, miR-24-3p, and miR-145-5p expression levels; calculating probability of developing AKI from AMI based on the at least two miRNA expression levels and a logistic regression model; comparing the probability with a predetermined standard; and determining that the human subject is at the risk of developing AKI when the probability is higher than the predetermined standard. A composition may be administered to the human subject for inhibiting development of AKI, if any.


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