The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2022
Filed:
Jun. 18, 2018
Applicant:
Zymeworks Inc., Vancouver, CA;
Inventors:
Nina E. Weisser, Delta, CA;
Gordon Yiu Kon Ng, Vancouver, CA;
Grant Raymond Wickman, Vancouver, CA;
Surjit Bhimarao Dixit, Richmond, CA;
Eric Escobar-Cabrera, Vancouver, CA;
Mario Sanches, Vancouver, CA;
Assignee:
Zymeworks Inc., Vancouver, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/32 (2006.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01); A61K 45/06 (2006.01); C07K 16/30 (2006.01); G01N 33/574 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/32 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61K 47/6803 (2017.08); A61K 47/6851 (2017.08); A61K 47/6855 (2017.08); A61K 47/6869 (2017.08); C07K 16/3015 (2013.01); C07K 16/3069 (2013.01); G01N 33/57492 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/41 (2013.01); C07K 2317/52 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/55 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.