The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 10, 2022

Filed:

Mar. 09, 2020
Applicant:

University of Kentucky Research Foundation, Lexington, KY (US);

Inventors:

Peixuan Guo, Columbus, OH (US);

Carlo M. Croce, Columbus, OH (US);

Tae Jin Lee, Columbus, OH (US);

Farzin Haque, Long Island City, NY (US);

Hui Li, Columbus, OH (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C07H 21/02 (2006.01); C12N 15/113 (2010.01); A61K 47/55 (2017.01); C12N 15/11 (2006.01); A61K 47/69 (2017.01); A61P 35/00 (2006.01); C12N 15/115 (2010.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); A61K 47/551 (2017.08); A61K 47/6929 (2017.08); A61P 35/00 (2018.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); B82Y 5/00 (2013.01); C12N 2310/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/52 (2013.01); C12N 2320/32 (2013.01);
Abstract

The presently-disclosed subject matter relates to an artificial RNA nanostructure molecule and method to treat brain tumor in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure containing a multiple branched RNA nanoparticle, a brain tumor targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanostructure composition to treat brain tumor in a subject having or at risk of having brain tumor.


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