The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2022
Filed:
Mar. 29, 2019
Applicant:
Sumitomo Dainippon Pharma Co., Ltd., Osaka, JP;
Inventors:
Seiji Kamioka, Toyonaka, JP;
Naoaki Shimada, Takatsuki, JP;
Wataru Hirose, Suita, JP;
Hitoshi Ban, Nishinomiya, JP;
Akihiko Yokoyama, Tsuruoka, JP;
Assignee:
Sumitomo Dainippon Pharma Co., Ltd., Osaka, JP;
Primary Examiner:
Int. Cl.
CPC ...
C07D 519/00 (2006.01); A61K 45/06 (2006.01); A61K 31/439 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention relates to the compound of formula (I) wherein p is 1 or 2, Ris —CFor the like, R, R, R, and Rare hydrogen atom or the like, X is —C(═O)—or the like, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.