The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2022
Filed:
Nov. 29, 2017
Bantam Pharmaceutical, Llc, New York, NY (US);
M. Arshad Siddiqui, Newton, MA (US);
Stephane Ciblat, Montreal, CA;
Martin Dery, Montreal, CA;
Lea Constantineau-Forget, Montreal, CA;
Chantal Grand-Maitre, Boisbriand, CA;
Nicolas Bruneau-Latour, Ste. Genevieve, CA;
Gerald W. Shipps, Boston, MA (US);
Alan B. Cooper, Kenilworth, NJ (US);
Vibha Oza, Acton, MA (US);
Matthew J. Kostura, Hillsborough, NC (US);
Michael Luther, Andover, MA (US);
Jedd Levine, Litchfield, CT (US);
Bantam Pharmaceutical, LLC, New York, NY (US);
Abstract
Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae (Ia), (Ib), (Ic), (Id) and (Ie), in which R, L, L, Q, L, R, L, R, L, and Rare as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.