The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 10, 2022

Filed:

Jun. 28, 2017
Applicant:

University of Kentucky Research Foundation, Lexington, KY (US);

Inventors:

Chang-Guo Zhan, Lexington, KY (US);

Fang Zheng, Lexington, KY (US);

Kai Ding, Lexington, KY (US);

Ziyuan Zhou, Lexington, KY (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/06 (2006.01); C07D 417/04 (2006.01); C07D 403/06 (2006.01); C07D 207/452 (2006.01); C07D 231/12 (2006.01); C07D 251/20 (2006.01); C07D 277/34 (2006.01); C07C 205/42 (2006.01); C07C 255/41 (2006.01);
U.S. Cl.
CPC ...
C07D 417/06 (2013.01); C07C 205/42 (2013.01); C07C 255/41 (2013.01); C07D 207/452 (2013.01); C07D 231/12 (2013.01); C07D 251/20 (2013.01); C07D 277/34 (2013.01); C07D 403/06 (2013.01); C07D 417/04 (2013.01);
Abstract

Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.


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