The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2022
Filed:
Dec. 21, 2016
Endosome Therapeutics, Inc., Pottstown, PA (US);
Nigel W. Bunnett, Parkville, AU;
Christopher John Porter, Parkville, AU;
Derek Cole, San Diego, CA (US);
Gareth Hicks, Wellesley, MA (US);
Junya Shirai, Osaka, JP;
Gavin Hirst, San Diego, CA (US);
Luigi Aurelio, Clayton, AU;
Endosome Therapeutics, Inc., Pottstown, PA (US);
Abstract
The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a linker and a lipid anchor suitable for anchoring the tripartite compound into a plasma membrane. The present invention also relates to a prodrug and a pharmaceutical composition comprising the tripartite compound and the use of the tripartite compound for the treatment of a disease or disorder mediated by endosomal G protein-coupled receptors signalling like NKR signalling.