Multifunctionalized polyethylene glycol derivative and preparation method therefor

Abstract

Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n, n, n, and nrespectively are the degrees of polymerization of the branch chains, Uand Uare trivalent branching groups connecting the core LPEG to two of the PEG branch chains, Fand Fcontain a functional group or a protected form Rthereof and may or may not contain a branched group G, correspondingly, the number of Ris one or more, Fand Fare either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.