The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2022
Filed:
Jun. 10, 2020
Applicant:
Protein Potential, Llc, Rockville, MD (US);
Inventors:
Yun Wu, Rockville, MD (US);
Dennis J. Kopecko, Silver Spring, MD (US);
B. Kim Lee Sim, Gaithersburg, MD (US);
Stephen L. Hoffman, Gaithersburg, MD (US);
Assignee:
Protein Potential, LLC, Rockville, MD (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/116 (2006.01); A61K 39/02 (2006.01); A61K 39/112 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0283 (2013.01); A61K 39/0275 (2013.01); A61K 39/116 (2013.01); A61K 2039/522 (2013.01); A61K 2039/523 (2013.01); A61K 2039/543 (2013.01); A61K 2039/70 (2013.01); Y02A 50/30 (2018.01);
Abstract
Disclosed is the attenuatedvaccine Ty21a utilized as a vector forand/or enterotoxogenicgenes stably integrated in the Ty21a chromosome. These genes include a heterologousO-antigen biosynthetic gene region that comprises the wzz gene and expressesform 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.