The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2022
Filed:
Apr. 17, 2018
The Regents of the University of Colorado, a Body Corporate, Denver, CO (US);
Travere Therapeutics Switzerland Gmbh, Rapperswil-Jona, CH;
Tomas Majtan, Aurora, CO (US);
Jan P. Kraus, Denver, CO (US);
Erez M. Bublil, Ets Efraim, IL;
Frank Glavin, Belmont, MA (US);
Marcia Sellos-Moura, West Newbury, MA (US);
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, Denver, CO (US);
TRAVERE THERAPEUTICS SWITZERLAND GMBH, Rapperswil-Jona, CH;
Abstract
The present invention provides a method of PEGylating a human truncated cystathionine β-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.