The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2022
Filed:
Nov. 18, 2015
International Stem Cell Corporation, Carlsbad, CA (US);
Elena S. Revazova, Pacific Palisades, CA (US);
Marina V. Pryzhkova, Moscow, RU;
Leonid N. Kuzmichev, Moscow, RU;
Jeffrey D. Janus, Frederick, MD (US);
International Stem Cell Corporation, Oceanside, CA (US);
Abstract
Methods of producing human stem cells are disclosed for parthenogenetically activating human oocytes by manipulation of Otension, including manipulation of Caunder high Otension and contacting oocytes with serine threonine kinase inhibitors under low Otension, isolating inner cell masses (ICMs) from the activated oocytes, and culturing the cells of the isolated ICMs under high Otension. Moreover, methods are described for the production of stems cells from activated oocytes in the absence of non-human animal products, including the use of human feeder cells/products for culturing ICM/stem cells. Stem cells produced by the disclosed methods are also described.