The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2022
Filed:
Oct. 31, 2016
Electrophoretics Limited, London, GB;
Ruprecht-karls-universität, Heidelberg, DE;
Dkfz Deutsches Krebsforschungszentrum, Heidelberg, DE;
Sasa Koncarevic, Sennfeld, DE;
Karsten Kuhn, Hofheim am Taunus, DE;
Peter Schulz-Knappe, Hemmingen, DE;
Ian Hugo Pike, Tonbridge, GB;
Christiane Opitz, Weinheim, DE;
Michael Platten, Heidelberg, DE;
ELECTROPHORETICS LIMITED, London, GB;
RUPRECHT-KARLS-UNIVERSITAT, Heidelberg, DE;
DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM, Heidelberg, DE;
Abstract
Tryptophan degradation is a key metabolic pathway controlling immune reactions and evidence suggests that during cancer progression generation of tryptophan metabolites may be fundamental for immune escape promoting the malignant phenotype of cancer cells in an autocrine fashion. The present invention relates to methods of measuring mass tag labelled tryptophan and metabolites thereof and methods using the labelled molecules for monitoring in a subject the effectiveness of a treatment and of disease recurrence after treatment, for stratifying patients and for diagnosing suppression of an immune response in a subject.