The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2022
Filed:
Aug. 24, 2017
Applicant:
Resolution Bioscience, Inc., Bellevue, WA (US);
Inventors:
Christopher Raymond, Bellevue, WA (US);
Lee Lim, Bellevue, WA (US);
Jennifer Hernandez, Bellevue, WA (US);
Assignee:
Resolution Bioscience, Inc., Kirkland, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6886 (2018.01); G16B 20/00 (2019.01); G16B 30/00 (2019.01); C12Q 1/68 (2018.01); C12Q 1/6809 (2018.01); G16B 30/10 (2019.01); G16B 20/40 (2019.01); G16B 20/10 (2019.01); G16B 25/10 (2019.01); G16B 20/20 (2019.01); C12Q 1/6806 (2018.01); C12Q 1/686 (2018.01); C12Q 1/6869 (2018.01); C12Q 1/6851 (2018.01); C40B 40/08 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12Q 1/68 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6809 (2013.01); C12Q 1/6869 (2013.01); G16B 20/00 (2019.02); G16B 20/10 (2019.02); G16B 20/20 (2019.02); G16B 20/40 (2019.02); G16B 25/10 (2019.02); G16B 30/00 (2019.02); G16B 30/10 (2019.02); C12Q 1/6851 (2013.01); C12Q 2525/191 (2013.01); C12Q 2545/114 (2013.01); C12Q 2563/159 (2013.01); C12Q 2563/179 (2013.01); C12Q 2600/156 (2013.01); C40B 40/08 (2013.01); G01N 2570/00 (2013.01); G01N 2800/7028 (2013.01);
Abstract
The present invention includes compositions and methods useful for the detection of a mutational change, SNP, translocation, inversion, deletion, change in copy number, or other genetic variation within a sample of cellular genomic DNA or cell-free DNA (cfDNA). In some embodiments, the compositions and methods of the present invention provide an extremely high level of resolution that is particularly useful in detecting copy number variations in a small fraction of the total cfDNA from a biological sample (e.g., blood).