The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2022
Filed:
Nov. 20, 2015
Applicant:
Duke University, Durham, NC (US);
Inventors:
Farshid Guilak, Durham, NC (US);
Jonathan M. Brunger, Durham, NC (US);
Charles A. Gersbach, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/11 (2006.01); A61P 25/28 (2006.01); A61K 35/28 (2015.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); A61K 35/28 (2013.01); A61K 38/1793 (2013.01); A61K 48/005 (2013.01); A61P 25/28 (2018.01); C12N 15/111 (2013.01); C12N 2310/20 (2017.05); C12N 2320/30 (2013.01);
Abstract
Disclosed herein are compositions and methods for cell therapy comprising an engineered cell. The present invention is directed to a composition for treating a subject having or suspected of having a disease, the composition comprising a modified cell comprising a modified endogenous gene, wherein an endogenous gene or fragment thereof is replaced with a transgene using a CRISPR/Cas9 system to generate the modified endogenous gene, the modified cell having an altered response to a cell signal or stimulus.