The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2022
Filed:
Dec. 28, 2017
Applicant:
Zonhon Biopharma Institute, Inc, Jiangsu, CN;
Inventors:
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/435 (2006.01); A61P 37/08 (2006.01); A61K 39/35 (2006.01); C12N 15/81 (2006.01);
U.S. Cl.
CPC ...
C07K 14/43531 (2013.01); A61K 39/35 (2013.01); A61P 37/08 (2018.01); C12N 15/815 (2013.01);
Abstract
A DNA sequence encoding Der p2 protein having a particular base sequence is codon-optimized for theexpression system, which is conducive to expressing Der p2 in. After gene optimization and adding an activating element to increase the expression of Der p2 in molecular level, it was found that Der p2 is expressed at a higher level as compared with the prior art and has biological activity similar to the natural protein.