The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2022
Filed:
Jan. 19, 2018
Zhejiang University, Hangzhou, CN;
Xiaowu Dong, Hangzhou, CN;
Bo Yang, Hangzhou, CN;
Yongzhou Hu, Hangzhou, CN;
Qiaojun He, Hangzhou, CN;
Qinjie Weng, Hangzhou, CN;
Wenhu Zhan, New York, NY (US);
Tao Liu, Hangzhou, CN;
GUANGZHOU LIXIN PHARMACEUTICAL CO., LTD., Guangzhou, CN;
Abstract
A polyfluoro-substituted aromatic heterocyclic derivative having the structure as represented by formula I or formula I', wherein at least one of Rand Ris a fluorine atom, and at least two substituents of Rc, Rd, Re, and Rf are fluorine atoms; and an optical isomer of the derivative, or a pharmaceutically acceptable salt or solvate of the same, or a pharmaceutically acceptable salt or solvate of the optical isomer of the same. A composition containing the polyfluoro-substituted aromatic heterocyclic derivative and an application of the composition in preparing an anti-tumour medicament. The compound provides significant inhibitory effects with respect to Akt1 and demonstrates strong proliferation inhibitory activity with respect to tumour cell lines such as an ovarian cancer cell line, a colon cancer cell line, and a prostate cancer cell line. Therefore, the compound may be used as an Akt inhibitor in the medicament for treating a cell proliferation-related solid tumour or blood cancer in the human or animal body.