The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2022
Filed:
Mar. 31, 2016
Oncosec Medical Incorporated, San Diego, CA (US);
Arya Bahrami, La Jolla, CA (US);
Douglas W. Brown, San Diego, CA (US);
Jean Campbell, Seattle, WA (US);
Richard J. Connolly, San Diego, CA (US);
Andy E. Denison, Temecula, CA (US);
Christopher S. Hayden, Winchester, CA (US);
Eric T. Johnson, Temecula, CA (US);
Robert H. Pierce, Seattle, WA (US);
Robert R. Ragland, Temecula, CA (US);
ONCOSEC MEDICAL INCORPORATED, San Diego, CA (US);
Abstract
An adaptive control method for controlling EP pulse parameters during electroporation (EP) of cells or tissue using an EP system includes providing a system for adaptive control to optimize EP pulse parameters including EP pulse parameters, applying voltage and current excitation signals to the cells, obtaining data from the current and voltage measurements, and processing the data to separate the desirable data from the undesirable data, extracting relevant features from the desirable data, applying at least a portion of the relevant features to a trained diagnostic model, estimating EP pulsing parameters based on an outcome of the applied relevant features, where the initialized EP pulsing parameters are based on the trained model and the relevant features, to optimize the EP pulsing parameters, and applying, by the generator, a first EP pulse based on the first pulsing parameters.