The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 03, 2022

Filed:

Oct. 11, 2019
Applicant:

Aarhus Universitet, Aarhus C, DK;

Inventors:

Claus Oxvig, Højbjerg, DK;

Jakob Hauge Mikkelsen, Horning, DK;

Malene Runge Jepsen, Aarhus N, DK;

Assignee:

Aarhus Universitet, Aarhus C, DK;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); G01N 33/60 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A61K 31/713 (2006.01); C07K 16/40 (2006.01); C12N 9/64 (2006.01); A61K 38/22 (2006.01); C07K 14/575 (2006.01); C07K 16/38 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 38/22 (2013.01); C07K 14/575 (2013.01); C07K 16/18 (2013.01); C07K 16/38 (2013.01); C07K 16/40 (2013.01); C12N 9/6489 (2013.01); C12Y 304/24079 (2013.01); C07K 2317/76 (2013.01); G01N 33/53 (2013.01);
Abstract

A method is provided of decreasing or increasing the activity of a Pappalysin polypeptide by decreasing or increasing the level of interacting Pappalysin and stanniocalcin polypeptides. A method is also provided of preventing, treating or ameliorating a clinical condition in a mammalian subject, such as a human being, said method comprising administering to said mammalian subject, such as human being an effective amount of a stanniocalcin polypeptide. Moreover, a method is provided of preventing, treating or ameliorating a clinical condition in a mammalian subject, such as a human being, said method comprising administering to said mammalian subject, such as human being an effective amount of an agent capable of antagonizing interaction of a stanniocalcin polypeptide with a Pappalysin polypeptide.


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