The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2022
Filed:
Feb. 23, 2018
Applicants:
University of South Florida, Tampa, FL (US);
University of Kansas, Lawrence, KS (US);
Inventors:
Chad Dickey, Tampa, FL (US);
Lindsey Shelton, Tampa, FL (US);
Brian Blagg, Lawrence, KS (US);
John Koren, Tampa, FL (US);
Laura Blair, Tampa, FL (US);
Assignees:
University of South Florida, Tampa, FL (US);
University of Kansas, Lawrence, KS (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7048 (2006.01); A61P 25/28 (2006.01); A61K 31/366 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7048 (2013.01); A61K 31/366 (2013.01); A61P 25/28 (2018.01);
Abstract
Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.