The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2022
Filed:
Jan. 25, 2017
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Jean Zhao, Brookline, MA (US);
Jing Ni, Chestnut Hill, MA (US);
Shaozhen Xie, Chestnut Hill, MA (US);
Assignee:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/7088 (2006.01); A61P 35/04 (2006.01); A61K 31/713 (2006.01); A61K 45/06 (2006.01); A61K 47/68 (2017.01); A61K 31/4184 (2006.01); A61K 31/436 (2006.01); A61K 31/551 (2006.01); A61K 39/395 (2006.01); C07K 16/40 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/4184 (2013.01); A61K 31/436 (2013.01); A61K 31/551 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 47/6871 (2017.08); A61P 35/04 (2018.01); C07K 16/40 (2013.01); C12N 15/1137 (2013.01); C07K 2317/52 (2013.01); C07K 2317/72 (2013.01); C12N 2310/11 (2013.01); C12N 2310/122 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2310/16 (2013.01); C12N 2310/531 (2013.01); C12N 2320/31 (2013.01);
Abstract
The present invention relates to methods of treating brain metastases using synergistic combinations of anti-PI3K and anti-mTOR therapies. It has also been determined that blocking PI3K and mTOR provides therapeutic benefit for treating brain metastases.