The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2022
Filed:
Aug. 30, 2017
Applicant:
Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, CN;
Inventors:
Yuelei Shen, Beijing, CN;
Yang Bai, Beijing, CN;
Yanan Guo, Beijing, CN;
Rui Huang, Beijing, CN;
Xiaofei Zhou, Beijing, CN;
Chaoshe Guo, Beijing, CN;
Assignee:
Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); C07H 21/04 (2006.01); C12N 15/63 (2006.01); C07K 14/705 (2006.01); C12N 15/90 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); C07K 14/70532 (2013.01); C12N 15/907 (2013.01); A01K 2207/15 (2013.01); A01K 2217/072 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); C07H 21/04 (2013.01); C12N 15/8509 (2013.01);
Abstract
Non-human animals, methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanized programmed death-ligand 1 (PD-L1, PDL1, or B7-H1). Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous PD-L1 gene so that the non-human animals express a humanized PD-L1 protein that includes a human portion and an endogenous portion (e.g., a non-human portion).