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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11312951 B1

PDFFull Text
Date of Patent:
Apr. 26, 2022

Filed:

May. 12, 2021

Systems and methods for host cell improvement utilizing epistatic effects

Applicant:

Zymergen Inc., Emeryville, CA (US);

Inventors:

Zachariah Serber, Kenwood, CA (US);

Erik Jedediah Dean, Lafayette, CA (US);

Shawn Manchester, Oakland, CA (US);

Katherine Gora, Oakland, CA (US);

Michael Flashman, Eureka, CA (US);

Erin Shellman, Seattle, WA (US);

Aaron Kimball, San Francisco, CA (US);

Shawn Szyjka, Martinez, CA (US);

Barbara Frewen, Alameda, CA (US);

Thomas Treynor, Berkeley, CA (US);

Kenneth S. Bruno, Walnut Creek, CA (US);

Assignee:

Zymergen Inc., Emeryville, CA (US);

Attorney:

Cooley LLP

Primary Examiner:

Lori A Clow

Int. Cl.
CPC ...
C12N 15/10 (2006.01); G16B 20/00 (2019.01); G16B 5/00 (2019.01); G16B 40/00 (2019.01); C12N 15/00 (2006.01); G16B 40/30 (2019.01); G16B 40/20 (2019.01); C12N 15/77 (2006.01); C12N 15/80 (2006.01); B01L 3/02 (2006.01); B01L 3/00 (2006.01); G01N 35/10 (2006.01); C12M 1/42 (2006.01); C12M 1/34 (2006.01); G01N 35/00 (2006.01); B01L 7/00 (2006.01); C12M 3/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1058 (2013.01); B01L 3/0275 (2013.01); B01L 3/5085 (2013.01); C12M 1/42 (2013.01); C12M 35/02 (2013.01); C12M 41/12 (2013.01); C12N 15/00 (2013.01); C12N 15/1075 (2013.01); C12N 15/1079 (2013.01); C12N 15/77 (2013.01); C12N 15/80 (2013.01); G01N 35/00871 (2013.01); G01N 35/10 (2013.01); G01N 35/1002 (2013.01); G16B 5/00 (2019.02); G16B 20/00 (2019.02); G16B 40/00 (2019.02); G16B 40/20 (2019.02); G16B 40/30 (2019.02); B01L 7/52 (2013.01); B01L 2200/025 (2013.01); B01L 2200/0689 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0627 (2013.01); B01L 2300/0672 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/18 (2013.01); B01L 2300/1894 (2013.01); C12M 3/00 (2013.01); C12M 35/00 (2013.01); G01N 2035/103 (2013.01); G01N 2035/1027 (2013.01); G01N 2035/1032 (2013.01); G01N 2035/1048 (2013.01); G01N 2035/1053 (2013.01); G01N 2035/1058 (2013.01);
Abstract

The present disclosure provides systems and methods for host cell improvement utilizing epistatic effects. The systems and methods described herein are host cell agnostic and therefore can be implemented across taxa. Furthermore, the disclosed systems and methods can be implemented to modulate or improve any host cell parameter of interest.

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