The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2022
Filed:
Jan. 29, 2018
Applicant:
Ruprecht-karls-universität Heidelberg, Heidelberg, DE;
Inventors:
Johannes Backs, Dossenheim, DE;
Zegeye Jebessa, Heidelberg, DE;
Lorenz Lehmann, Heidelberg, DE;
Hugo Katus, Heidelberg, DE;
Oliver Müller, Dossenheim, DE;
Assignee:
RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, Heidelberg, DE;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/12 (2006.01); A61K 38/48 (2006.01); C12N 9/80 (2006.01); C12N 9/10 (2006.01); A61K 38/45 (2006.01); A61K 38/50 (2006.01); C12Q 1/48 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1029 (2013.01); A61K 38/45 (2013.01); A61K 38/48 (2013.01); A61K 38/50 (2013.01); C12N 9/80 (2013.01); C12Q 1/48 (2013.01); C12Y 203/01051 (2013.01); C12Y 305/01098 (2013.01); G01N 2333/91057 (2013.01); G01N 2500/04 (2013.01); G01N 2500/20 (2013.01);
Abstract
The present invention relates to Abhydrolase containing domain 5 (ABHD5) and N-terminal fragments of HDAC4 (HDAC4-NT) and variants of the aforementioned peptides for the treatment and prevention of heart failure. The present invention further provides vectors for the cardiomyocyte-specific expression of said peptides and a test system comprising ABHD5 for the identification of novel compounds which are useful for the treatment of heart failure.