The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 26, 2022

Filed:

Jul. 22, 2020
Applicant:

Aerie Pharmaceuticals, Inc., Bedminster, NJ (US);

Inventors:

Mitchell A. deLong, Chapel Hill, NC (US);

Jill M. Sturdivant, Chapel Hill, NC (US);

Cynthia L. Lichorowic, Raleigh, NC (US);

Andriy Kornilov, Ypsilanti, MI (US);

Assignee:

Aerie Pharmaceuticals, Inc., Bedminster, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/02 (2006.01); C07D 401/12 (2006.01); C07D 217/02 (2006.01); C07D 405/12 (2006.01); C07D 417/12 (2006.01); C07D 217/24 (2006.01); C07D 217/22 (2006.01); C07D 401/04 (2006.01); C07D 405/14 (2006.01); C07C 69/76 (2006.01); A61P 27/06 (2006.01); C07D 401/14 (2006.01); C07D 409/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61P 27/06 (2018.01); C07C 69/76 (2013.01); C07D 217/02 (2013.01); C07D 217/22 (2013.01); C07D 217/24 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 417/12 (2013.01); C07C 2601/02 (2017.05);
Abstract

Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.


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