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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11311609 B1

PDFFull Text
Date of Patent:
Apr. 26, 2022

Filed:

Feb. 08, 2018

Regulating chimeric antigen receptors

Applicant:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Inventors:

James Bradner, Weston, MA (US);

Justin Roberts, Cambridge, MA (US);

Behnam Nabet, Boston, MA (US);

Georg Winter, Vienna, AT;

Andrew J. Phillips, Cambridge, MA (US);

Timothy P. Heffernan, Cambridge, MA (US);

Dennis Buckley, Jamaica Plain, MA (US);

Assignee:

DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);

Attorneys:

Burns & Levinson, LLP

Daniel W. Clarke

Shawn P. Foley

Primary Examiner:

Phuong Huynh

Int. Cl.
CPC ...
A61K 38/52 (2006.01); A61P 37/06 (2006.01); A61K 35/17 (2015.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 495/04 (2006.01); C07D 495/14 (2006.01); C07J 43/00 (2006.01); C07K 14/535 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C12N 9/90 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
A61K 38/52 (2013.01); A61K 35/17 (2013.01); A61P 37/06 (2018.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 495/04 (2013.01); C07D 495/14 (2013.01); C07J 43/003 (2013.01); C07K 14/535 (2013.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C07K 16/2803 (2013.01); C07K 16/2878 (2013.01); C07K 16/2896 (2013.01); C07K 16/32 (2013.01); C12N 5/0636 (2013.01); C12N 5/0638 (2013.01); C12N 9/90 (2013.01); C12Y 502/01008 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01);
Abstract

This invention is in the area of compositions and methods for regulating chimeric antigen receptor immune effector cell, for example T-cell (CAR-T), therapy to modulate associated adverse inflammatory responses, for example, cytokine release syndrome and tumor lysis syndrome, using targeted protein degradation.

Find Patent Forward Citations

Bradner, James. (2022). Regulating chimeric antigen receptors (U.S. Patent No. 11311609). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11311609

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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