The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2022
Filed:
Mar. 12, 2019
Applicant:
Georgetown University, Washington, DC (US);
Inventors:
Christopher Albanese, Pelham, NY (US);
Aisha Naeem, Springfield, VA (US);
Assignee:
GEORGETOWN UNIVERSITY, Washington, DC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61P 35/00 (2006.01); A61K 31/475 (2006.01); A61K 31/704 (2006.01);
U.S. Cl.
CPC ...
A61K 38/2292 (2013.01); A61K 31/475 (2013.01); A61K 31/704 (2013.01); A61P 35/00 (2018.01);
Abstract
Provided herein is a method of treating medulloblastoma or glioblastoma in a subject by administering to the subject a PI3K activator (e.g., thymosin β-4 or a derivative thereof) and one or more chemotherapeutic agents and/or radiation. The combination therapy is effective in the treatment of medulloblastoma or glioblastoma characterized by cells with elevated p53 levels.