The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2022
Filed:
May. 05, 2021
Modernatx, Inc., Cambridge, MA (US);
Joshua Frederick, Charlestown, MA (US);
Susannah Hewitt, Jamaica Plain, MA (US);
Ailin Bai, Newton, MA (US);
Stephen Hoge, Brookline, MA (US);
Vladimir Presnyak, Manchester, NH (US);
Iain McFadyen, Arlington, MA (US);
Kerry Benenato, Sudbury, MA (US);
Ellalahewage Sathyajith Kumarasinghe, Harvard, MA (US);
ModernaTX, Inc., Cambridge, MA (US);
Abstract
The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional fragments thereof, and fusion proteins comprising IL12. In some embodiments, the open reading frame is sequence-optimized. In particular embodiments, the disclosure provides sequence-optimized polynucleotides comprising nucleotides encoding the polypeptide sequence of human IL12, or sequences having high sequence identity with those sequence optimized polynucleotides.