The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2022
Filed:
Jun. 19, 2019
Quegen Biotech Co., Ltd., Gyeonggi-do, KR;
Chul Su Yang, Gyeonggi-do, KR;
Byeong Hee Park, Gyeonggi-do, KR;
Je Kyoung Kim, Gyeonggi-do, KR;
Yong Man Jang, Gyeonggi-do, KR;
Soo Dong Kim, Seoul, KR;
Min Ji Kim, Gyeonggi-do, KR;
Quegen Biotech Co., Ltd., Gyeonggi-do, KR;
Abstract
The present invention relates to a composition for use in preventing, alleviating, or treating inflammatory disease, or an anti-inflammatory composition, which comprises: β-1,3-glucan; and the peptide composed of the amino acid sequence of SEQ ID NO: 4. The present invention also relates to an antibacterial composition against bacteria causative of sepsis, which comprises: β-1,3-glucan; the peptide composed of the amino acid sequence of SEQ ID NO: 4; and an antibiotic. The present invention also relates to a method for preventing or treating an inflammatory disease, the method comprising a step of administering β-1,3-glucan; and the peptide composed of the amino acid sequence of SEQ ID NO: 4 to a patient. Accordingly, when β-1,3-glucan and a peptide consisting of an amino acid sequence of SEQ ID NO: 4 are included, since the level of reactive oxygen species (ROS), sepsis-causing bacteria or an inflammatory cytokine of a sepsis mouse can be lowered, and the survival rate of the mouse can be significantly increased, they are effective for use in a composition or method for preventing, alleviating or treating an inflammatory disease such as sepsis. Particularly, the ROS generated by a phagocyte is specifically reduced and when used in combination with an antibiotic, ROS, sepsis-causing bacteria or the expression level of an inflammatory cytokine can be significantly decreased, thereby significantly increasing a survival rate, resulting in a more excellent effect.