The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2022
Filed:
Jul. 23, 2018
Applicant:
Vascular Biogenics Ltd., Modiin, IL;
Inventors:
Eyal Breitbart, Hashmonaim, IL;
Andrea Leubitz, Efrat, IL;
Erez Feige, Hemed, IL;
Richard Penson, Braintree, MA (US);
Assignee:
Vascular Biogenetics Ltd., Modiin, IL;
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/79 (2006.01); C07H 21/04 (2006.01); A61K 35/761 (2015.01); C12N 15/86 (2006.01); C07K 14/705 (2006.01); A61K 31/337 (2006.01); A61K 31/713 (2006.01); A61K 45/06 (2006.01); C12N 7/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/761 (2013.01); A61K 9/0019 (2013.01); A61K 31/337 (2013.01); A61K 31/713 (2013.01); A61K 45/06 (2013.01); A61K 48/00 (2013.01); A61K 48/0058 (2013.01); C07K 14/70503 (2013.01); C07K 14/70578 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2710/10043 (2013.01); C12N 2710/10332 (2013.01); C12N 2800/24 (2013.01); C12N 2830/008 (2013.01);
Abstract
The invention provides methods of reducing or decreasing a size of a tumor or eliminating a tumor by inhibiting, decreasing, or reducing neo-vascularization or angiogenesis in a tumor in a patient by administering an adenovirus comprising a nucleic acid construct comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter. Also provided is a homogeneous population of an adenovirus comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter and its uses thereof.