The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2022
Filed:
Jul. 12, 2019
Applicant:
Yale University, New Haven, CT (US);
Inventors:
Ranjit Bindra, New Haven, CT (US);
Peter Glazer, Guilford, CT (US);
Parker Sulkowski, Guilford, CT (US);
Brian Shuch, New Haven, CT (US);
Assignee:
YALE UNIVERSITY, New Haven, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/55 (2006.01); A61K 31/498 (2006.01); A61K 31/445 (2006.01); A61K 31/4196 (2006.01); A61K 31/4164 (2006.01); A61P 35/00 (2006.01); A61K 31/502 (2006.01); A61K 31/166 (2006.01); A61K 31/454 (2006.01); A61K 31/4184 (2006.01); A61K 31/215 (2006.01); A61K 31/04 (2006.01); A61K 31/47 (2006.01); A61K 31/145 (2006.01); A61K 31/5025 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/502 (2013.01); A61K 31/04 (2013.01); A61K 31/145 (2013.01); A61K 31/166 (2013.01); A61K 31/215 (2013.01); A61K 31/4184 (2013.01); A61K 31/454 (2013.01); A61K 31/47 (2013.01); A61K 31/5025 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01);
Abstract
In various aspects and embodiments the invention provides a method of treating or preventing a cancer in a mammalian subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of at least one compound selected from the group consisting of a DNA repair inhibitor, a DNA strand break repair inhibitor, and a homologous recombination (HR) repair inhibitor, wherein cells in the cancer comprise a fumarate hydratase (FH) and/or succinate dehydrogenase (SDH) mutation.