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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11306305 B1

PDFFull Text
Date of Patent:
Apr. 19, 2022

Filed:

Sep. 22, 2017

Tuning crispr/cas9 activity with chemically modified nucleotide substitutions

Applicants:

Board of Trustees of Southern Illinois University, Springfield, IL (US);

The Royal Institution for the Advancement of Learning/mcgill University, Montreal, CA;

Inventors:

Keith Gagnon, Carbondale, IL (US);

Masad Damha, Montreal, CA;

Elise Malek-Adamian, Ottawa, CA;

Maryam Habibian, Montreal, CA;

Daniel Timothy O'Reilly, Waterlooville, GB;

Zachery Kartje, Valparaiso, IN (US);

Assignees:

Board of Trustees of Southern Illinois University, Carbondale, IL (US);

The Royal Institution for the Advancement of Learning/McGill University;

Attorney:

Husch Blackwell LLP

Primary Examiner:

Suzanne M Noakes

Assistant Examiner:

Jae W Lee

Int. Cl.
CPC ...
C12N 15/10 (2006.01); A61K 48/00 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 15/102 (2013.01); A61K 48/00 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/113 (2013.01); C12N 15/90 (2013.01); C12N 15/907 (2013.01); C12N 2310/20 (2017.05); C12N 2310/315 (2013.01); C12N 2310/318 (2013.01); C12N 2310/319 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/344 (2013.01); C12N 2310/346 (2013.01); C12N 2800/80 (2013.01);
Abstract

The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.

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Gagnon, Keith. (2022). Tuning crispr/cas9 activity with chemically modified nucleotide substitutions (U.S. Patent No. 11306305). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11306305

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