The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 19, 2022

Filed:

Sep. 08, 2018
Applicants:

Avita International Ltd., Tortola, VG;

Fundaç Ão Butantan, São Paulo, BR;

Inventors:

Irina Kerkis, São Paulo, BR;

Cristiane Valverde Wenceslau, São Paulo, BR;

Assignees:

AVITA INTERNATIONAL LTD., Tortola, VG;

FUNDAÇÃO BUTANTAN, Sao Paulo, BR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0775 (2010.01); A61K 35/32 (2015.01); A61K 9/00 (2006.01); C07K 14/705 (2006.01); A61P 35/00 (2006.01); A61P 25/00 (2006.01); A61K 35/28 (2015.01); C12N 5/0793 (2010.01); C12N 5/079 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0664 (2013.01); A61K 9/0019 (2013.01); A61K 35/28 (2013.01); A61K 35/32 (2013.01); A61P 25/00 (2018.01); A61P 35/00 (2018.01); C07K 14/70585 (2013.01); C07K 14/70596 (2013.01); C12N 5/0619 (2013.01); C12N 5/0621 (2013.01); C12N 5/0622 (2013.01); C12N 2500/25 (2013.01); C12N 2500/62 (2013.01); C12N 2501/31 (2013.01); C12N 2501/39 (2013.01); C12N 2506/1361 (2013.01); C12N 2533/12 (2013.01); C12N 2533/30 (2013.01); C12N 2533/90 (2013.01);
Abstract

The invention provides a method of producing human immature dental pulp stem cells (hIDPSCs) expressing CD44 and CD13 and lacking expression of CD146. The invention also provides compositions for use in the treatment of a neurological disease or condition selected from the group consisting of Parkinson's disease (PD), multiple sclerosis, amyotrophic lateral sclerosis (ALS), stroke, autoimmune encephalomyelitis, diabetic neuropathy, glaucomatous neuropathy, Alzheimer's disease, Huntington's disease (HD), autism, schizophrenia, stroke, ischemia, a motor disorder, and a convulsive disorder.


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