The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
Dec. 27, 2018
Bristol-myers Squibb Company, Princeton, NJ (US);
Cytomx Therapeutics, Inc., South San Francisco, CA (US);
Bryan C. Barnhart, San Francisco, CA (US);
Brigitte Devaux, Palo Alto, CA (US);
Aaron P. Yamniuk, Lawrenceville, NJ (US);
Shannon L. Okada, Seattle, WA (US);
Brenda L. Stevens, Seattle, WA (US);
James William West, South San Francisco, CA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
CytomX Therapeutics, Inc., South San Francisco, CA (US);
Abstract
Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.