The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
Jun. 20, 2019
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Yusheng Xiong, Plainsboro, NJ (US);
Thomas Joseph Tucker, North Wales, PA (US);
Chengwei Wu, Ambler, PA (US);
Elisabetta Bianchi, Rome, IT;
Danila Branca, Pomezia, IT;
Angela Dawn Kerekes, Plainfield, NJ (US);
Abbas M. Walji, Lansdale, PA (US);
Hubert B. Josien, Jersey City, NJ (US);
Fa-Xiang Ding, Staten Island, NJ (US);
Hyewon Youm, Berkeley Heights, NJ (US);
Alessia Santoprete, Rome, IT;
Raffaele Ingenito, Pomezia, IT;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Disclosed are compounds of Formula I, or a salt thereof cyclic polypeptide of Formula I: Formula I where A, B, E, R, and Rare as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions