The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
Mar. 17, 2017
Mission Therapeutics Limited, Cambridge, GB;
Alison Jones, Cambridge, GB;
Mark Ian Kemp, Cambridge, GB;
Martin Lee Stockley, Cambridge, GB;
Michael David Woodrow, Cambridge, GB;
MISSION THERAPEUTICS LIMITED, Cambridge, GB;
Abstract
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 7 or ubiquitin specific peptidase 7 (USP7). The invention further relates to the use of DUB or desumoylating inhibitors in the treatment of cancer. Described herein are compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Reach independently represent hydrogen, optionally substituted C-Calkyl or Rand Rtogether form an optionally substituted C-Ccycloalkyl ring, or Rand Rtogether form an optionally substituted C-Ccycloalkyl ring; A is a 5 membered nitrogen-containing aromatic ring and is substituted with at least one optionally substituted 5 to 10 membered monocyclic or bicyclic heteroaryl or aryl ring attached through an optional linker.